The significance of the protein IL-18 in ulcerative colitis was debated and not understood. A new study found that increased levels of IL-18 promoted the pathological changes associated with colitis:
….demonstrating that colitis severity is controlled at the level of IL-18 signaling in intestinal epithelial cells.
More research will surely follow on how to inhibit IL-18 which may lead to novel treatments.
We have a thread about ulcerative colitis on the Ecoja forums.